Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

DJ McBride; D Etemadmoghadam; SL Cooke; K Alsop; J George; A Butler; J Cho; D Galappaththige; C Greenman; KD Howarth; KW Lau; CK Ng; K Raine; J Teague; DC Wedge; AO Cancer Study Group; X Caubit; MR Stratton; JD Brenton; PJ Campbell; PA Futreal; DDL Bowtell

Journal article

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

DJ McBride, D Etemadmoghadam, SL Cooke, K Alsop, J George, A Butler, J Cho, D Galappaththige, C Greenman, KD Howarth, KW Lau, CK Ng, K Raine, J Teague, DC Wedge, AO Cancer Study Group, X Caubit, MR Stratton, JD Brenton, PJ Campbell Show all

Journal of Pathology | WILEY | Published : 2012

DOI: 10.1002/path.4042

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Abstract

The application of paired-end next generation sequencing approaches has made it possible to systematically characterize rearrangements of the cancer genome to base-pair level. Utilizing this approach, we report the first detailed analysis of ovarian cancer rearrangements, comparing high-grade serous and clear cell cancers, and these histotypes with other solid cancers. Somatic rearrangements were systematically characterized in eight high-grade serous and five clear cell ovarian cancer genomes and we report here the identification of > 600 somatic rearrangements. Recurrent rearrangements of the transcriptional regulator gene, TSHZ3, were found in three of eight serous cases. Comparison to br..

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